The 3rd edition of Hormones offers a comprehensive treatment of the hormones of humans all viewed from the context of current theories of their action in the framework of our current understanding their physiological actions as well as their molecular structures, and those of their receptors. This new edition of Hormones is intended to be used by advanced undergraduates and graduate students in the biological sciences. It will also provide useful background information for first year medical students as they engage in studies which are increasingly problem-based rather than discipline-focused. As the field of endocrinology itself has expanded so much in the past two decades, the up to date presentation of the basics presented in this book will be a solid foundation on which more specialized considerations can be based.
New to this Edition: Hormones, 3rd Edition is organized with two introductory chapters followed by 15 chapters on selected topics of the molecular biology of the major endocrine systems operative in humans. Coverage, for the first time of the following hormones; ghrelin, oxyntomodulin, kisspeptin, adrenomedullin, FGF23, erythropoietin, VIP and extended coverage of NO. Coverage of the hypothalamus has been integrated with the anterior pituitary because of the intimate functional and relationship between the two. Consideration of the role of hormones in cancer has been integrated into the chapters on the relevant hormones. Each of these areas occupies a unique niche in our understanding of the biological world and is part of the universality of signaling systems and how they govern biological systems.
Key Features
- Organized with two introductory chapters, followed by 15 chapters on selected topics of the molecular biology of the major human endocrine systems
- New full color format includes over 300 full color, completely redrawn images
- Companion web site will host all images from the book as PPT slides and .jpeg files
- All chapters have been completely updated and revitalized. Coverage of the hypothalamus has been integrated into the anterior pituitary chapter and coverage of the thymus has been eliminated and left to immunology textbooks
- Provides essential basics for advanced undergraduates and graduate students in the biological sciences, as well as first year medical students as they engage in studies which are increasingly problem-based rather than discipline-focused
- Preface
- About the Cover
- Front Cover Image
- Back Cover Image
- Chapter 1. Hormones: An Introduction
- I Overview of Hormones
- II Hormone Receptors
- III Mechanisms of Hormone Action
- IV Clinical Aspects
- Further Reading
- Chapter 2. Steroid Hormones: Chemistry, Biosynthesis, and Metabolism
- I Introduction
- II Chemistry of Steroids
- III Biosynthesis of Steroids
- IV Serum Binding Proteins for Steroid Hormones
- Further Reading
- Chapter 3. The Hypothalamus and Anterior Pituitary
- I Introduction
- II Anatomical Relationships
- III Structure, Synthesis, Secretion, and Target Cells of the Hypothalamic Releasing Hormones
- IV Chemistry of the Anterior Pituitary Hormones
- V Regulation and Biological Actions of Growth Hormone and Prolactin
- VI The Hypothalamus and Appetite Regulation
- VII Clinical Aspects
- Further Reading
- Chapter 4. Posterior Pituitary Hormones
- I Introduction
- II Anatomy of the Posterior Pituitary
- III Chemistry, Biosynthesis, and Secretion of the Posterior Pituitary Hormones
- IV Biological Actions of Arginine Vasopressin (AVP)
- V Biological Actions of Oxytocin
- VI Clinical Aspects
- Further Reading
- Chapter 5. Thyroid Hormones
- I Introduction
- II Anatomy of the Thyroid Gland
- III Chemistry of the Thyroid Hormones
- IV Synthesis and Secretion of Thyroid Hormones
- V Regulation of Thyroid Hormone Secretion
- VI Biological Actions of T3
- VII Clinical Aspects
- Further Reading
- Chapter 6. Pancreatic Hormones: Insulin and Glucagon
- I Introduction
- II Anatomical, Morphological, and Physiological Relationships
- III Chemistry, Biochemistry, and Biological Activities of the Pancreatic Hormones
- IV Clinical Aspects
- Further Reading
- Chapter 7. Gastrointestinal Hormones
- I Introduction
- II Anatomical and Physiological Relationships
- III Biochemical Properties and Molecular Actions
- IV Clinical Aspects
- Further Reading
- Chapter 8. Eicosanoids
- I Introduction
- II Structure and Nomenclature of Eicosanoids
- III Synthesis and Inactivation of Eicosanoids
- IV Eicosanoid Receptors and Signaling
- V Examples of Biological Actions of Prostaglandins
- VI Clinical Aspects
- Further Reading
- Chapter 9. Calcium-Regulating Hormones: Vitamin D, Parathyroid Hormone, Calcitonin, and Fibroblast Growth Factor 23
- I Introduction
- II Anatomical and Physiological Relationships
- III Chemistry and Biochemistry
- IV Biology and Molecular Actions
- V Clinical Aspects
- Further Reading
- Chapter 10. Adrenal Corticoids
- I Introduction
- II Anatomy
- III Biochemistry and Biosynthesis of Adrenal Steroids and Testosterone Steroids
- IV Biological and Molecular Actions of Glucocorticoids
- V Clinical Aspects
- Further Reading
- Chapter 11. Hormones of the Adrenal Medulla
- I Introduction
- II Anatomical and Physiological Relationships
- III Chemistry and Biochemistry of the Catecholamines
- IV Biological Actions of Catecholamines
- V Clinical Aspects
- Further Reading
- Chapter 12. Androgens
- I Introduction
- II Anatomy of the Male Reproductive System
- III Chemistry and Metabolism of Androgens
- IV Regulation of Androgen Production
- V Biological Responses to Androgens
- VI Clinical Aspects
- Further Reading
- Chapter 13. Estrogens and Progestins
- I Introduction
- II Anatomy of the Female Reproductive System
- III Chemistry and Metabolism of Female Steroid Hormones
- IV Hypothalamic-Pituitary-Ovary Axis
- V Biological Responses to Female Sex Steroids
- VI Clinical Aspects
- Further Reading
- Chapter 14. Hormones of Pregnancy, Parturition and Lactation
- I Introduction
- II Anatomical Relationships and the Beginning of Pregnancy
- III Chemistry, Biochemistry, and Activity of the Hormones of Pregnancy
- IV Parturition
- V Lactation
- VI Clinical Aspects
- Further Reading
- Chapter 15. Hormones Related to the Kidney and Cardiovascular System
- I Introduction
- II Anatomical, Morphological, and Physiological Relationships
- III Homeostasis of Fluid, Electrolytes, and Blood Pressure
- IV Hormones and Blood Cell Production
- V Clinical Aspects
- Further Reading
- Chapter 16. The Pineal Gland
- I Introduction
- II Anatomical Features of the Pineal Gland
- III Synthesis and Secretion of Melatonin
- IV Biological Actions of melatonin
- V Clinical Aspects
- Further Reading
- Chapter 17. Growth Factors
- I Introduction
- II Epidermal Growth Factor
- III Fibroblast Growth Factor Family
- IV Platelet Derived Growth Factors
- V Insulin-Like Growth Factors
- VI Transforming Growth Factor β
- VII Clinical Aspects
- Further Reading
- Appendix A
- Appendix B
- Appendix C
- Appendix D
- Appendix E
- Appendix F
- Units of Measurement in Biological Systems
- Index
Weiss/Refetoff, Genetic Diagnosis of Endocrine Disorders, 2nd Edition, 9780128008928, $99.95, 352 pp., forthcoming 2015, AP/Elsevier
New et.al., Genetic Steroid Disorders, 9780124160064, $149.95, 394 pp., 10/2013, AP/Elsevier
Advanced undergraduates and graduate students in the biological sciences (physiology, biochemistry, cell biology, ) in courses covering cellular and molecular endocrinology; first year medical students as they engage in studies which are increasingly problem-based rather than discipline-focused