Abbreviations

Online Study Guide

Preface

The Academic Cell Approach

Introduction to the Online Study Guide

Biographies: Authors

Contributors

Acknowledgments

Part I: Basic Immunology

Chapter 1. Introduction to the Immune Response

Abstract

A Historical Orientation

B The Nature of the Immune Response

C Types of Immune Responses: Innate and Adaptive

D Interplay between the Innate and Adaptive Responses

E Clinical Immunology

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Chapter 2. Components of the Immune System

Abstract

A Cells of the Immune System

B How Leukocytes Communicate

C Lymphoid Tissues

D Cellular Movement in the Immune System

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Chapter 3. Innate Immunity

Abstract

A Non-Inducible Innate Mechanisms

B Inducible Innate Mechanisms

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Chapter 4. The B Cell Receptor: Proteins and Genes

Abstract

A Immunoglobulin Proteins

B Immunoglobulin Genes

C Antibody–Antigen Interaction

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Chapter 5. B Cell Development, Activation and Effector Functions

Abstract

A B Cell Development: Maturation Phase

B B Cell Development: Differentiation Phase

C Effector Functions of Antibodies

D Immunoglobulin Isotypes in Biological Context

E Sources of Laboratory and Clinical Antibodies

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Chapter 6. The Major Histocompatibility Complex

Abstract

A Overview of the Major Histocompatibility Complex

B MHC Class I and Class II Proteins

C MHC Class I and Class II Genes

D Physiology of the MHC

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Chapter 7. Antigen Processing and Presentation

Abstract

A Overview of Antigen Processing and Presentation

B Nature of Cells That Can Activate T Cells

C Major Antigen Processing and Presentation Pathways

D Other Methods of Antigen Presentation

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Chapter 8. The T Cell Receptor: Proteins and Genes

Abstract

A TCR Proteins and Associated Molecules

B TCR Genes

C TCR–Antigen Interaction

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Chapter 9. T Cell Development, Activation and Effector Functions

Abstract

A T Cell Development

B T Cell Activation

C Th Cell Differentiation and Effector Function

D Tc Cell Differentiation and Effector Function

E Termination of Effector T Cell Responses

F Memory T Cells

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Chapter 10. Regulation of Immune Responses in the Periphery

Abstract

A Lymphocyte Tolerance in the Periphery

B Regulation of Lymphocyte Responses in the Periphery

C Special Tolerance Situations

D Experimental Tolerance

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Chapter 11. NK, γδ T and NKT Cells

Abstract

A Natural Killer (NK) Cells

B γδ T Cells

C NKT Cells

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Chapter 12. Mucosal and Cutaneous Immunity

Abstract

A Mucosal Immunity

B Cutaneous Immunity

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Part II: Clinical Immunology

Chapter 13. Immunity to Infection

Abstract

A General Features of Host–Pathogen Encounters

B Immunity to Extracellular Bacteria

C Immunity to Intracellular Bacteria

D Immunity to Viruses

E Immunity to Parasites

F Immunity to Fungi

G Prions

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Chapter 14. Vaccination

Abstract

A Introduction

B Vaccine Design

C Types of Vaccines

D Adjuvants and Delivery Vehicles

E Prophylactic Vaccines

F Vaccines in the Real World

G Future Directions

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Chapter 15. Immunodeficiency

Abstract

A Primary Immunodeficiency

B HIV Infection and Acquired Immunodeficiency Syndrome (AIDS)

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Chapter 16. Tumor Immunology

Abstract

A Tumor Biology

B Tumor Antigens

C Immune System Function in the Tumor Microenvironment

D Conventional Cancer Therapy

E Immunotherapy

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Chapter 17. Transplantation

Abstract

A The Nature of Transplantation

B The Molecular Basis of Graft Rejection

C Solid Organ Transplantation

D Minimizing Graft Rejection

E Hematopoietic Stem Cell Transplantation

F Blood Transfusions

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Chapter 18. Immune Hypersensitivity

Abstract

A Type I Hypersensitivity: IgE-Mediated or Immediate

B Type II Hypersensitivity: Direct Antibody-Mediated Cytotoxic Hypersensitivity

C Type III Hypersensitivity: Immune Complex-Mediated Hypersensitivity

D Type IV Hypersensitivity: Delayed Type or Cell-Mediated Hypersensitivity

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Chapter 19. Autoimmune Diseases

Abstract

A What is an Autoimmune Disease?

B Mechanisms Underlying Autoimmune Diseases

C Examples of Autoimmune Diseases

D Determinants of Autoimmune Diseases

E Therapy of Autoimmune Diseases

F Autoinflammatory Disorders

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Chapter 20. Hematopoietic Cancers

Abstract

A Overview of the Biology and Treatment of Hematopoietic Cancers

B Leukemias

C Myelomas

D Lymphomas

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Appendix A. Selected Landmark Discoveries in Immunology

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Appendix B. Nobel Prizes Awarded for Work in Immunology

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Appendix C. Comparative Immunology

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Appendix D. Selected CD Markers

Appendix E. Cytokines, Chemokines and Receptors

Appendix F. Selected Immunological Techniques

I Experimental Techniques Using Antibodies

II The Polymerase Chain Reaction

III HLA Typing Techniques

IV Laboratory Mouse Strains

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Glossary

Index