Mims' Pathogenesis of Infectious Disease,
Edition 6
By Anthony A. Nash, Robert G. Dalziel and J. Ross Fitzgerald

Publication Date: 22 Jan 2015
Mims' Pathogenesis of Infectious Disease is the landmark book in the field of infectious disease. The new, revised edition of this work provides a comprehensive, up-to-date description of the mechanisms of microbial infection and the pathogenesis of infectious disease. Presented in a clear, accessible style, it deals in an integrated manner with the spectrum of microorganisms, describing the factors common to all infectious diseases. Molecular biology, pathology, and immunology are brought together to explain the mechanisms for spread, immune response, and recovery.

Key Features

  • Describes the origin and molecular biology of pandemic influenza, HIV1, and HIV2 as well as the recent work on papillomaviruses, herpesviruses, BSE, and variant CJD
  • Contains the latest data on tuberculosis, microbial evasion of immune defenses, and the spread of antibiotic resistance genes among bacteria
  • Provides an update on vaccines, prions, immune evasion, and microbial ligands and receptors
  • Gives an up-to-date picture of the global burden of infectious diseases
About the author
By Anthony A. Nash, University of Edinburgh, UK; Robert G. Dalziel, University of Edinburgh, UK and J. Ross Fitzgerald, University of Edinburgh, UK
Table of Contents
  • Preface
  • Chapter 1. General Principles
    • Bibliography
  • Chapter 2. Attachment to and Entry of Microorganisms into the Body
    • Introduction
    • Adhesion/Entry: Some General Considerations
    • The Skin
    • Respiratory Tract
    • Gastrointestinal Tract
    • Oropharynx
    • Urinogenital Tract
    • Conjunctiva
    • The Normal Microbiota
    • Exit of Microorganisms from the Body
    • Bibliography
  • Chapter 3. Early Stages of Infection After Pathogen Entry
    • Growth in Epithelial Cells
    • Intracellular Microorganisms and Spread Through the Body
    • Subepithelial Invasion
    • Nutritional Requirements of Invading Microbes
    • Bibliography
  • Chapter 4. Encounter of Microbes with Phagocytic Cells
    • Cell Biology of Phagocytosis
    • Phagocytosis in Polymorphonuclear Leucocytes
    • Phagocytosis in Macrophages
    • Microbial Strategy in Relation to Phagocytes
    • Growth in the Phagocytic Cell
    • Killing the Phagocyte
    • Entry into the Host Cell Other Than by Phagocytosis
    • Consequences of Defects in the Phagocytic Cell
    • Summary
    • Bibliography
  • Chapter 5. The Spread of Microbes Through the Body
    • Direct Spread
    • Microbial Factors Promoting Spread
    • Spread Via Lymphatics
    • Spread Via the Blood
    • Spread Via Other Pathways
    • Bibliography
  • Chapter 6. The Immune Response to Infection
    • Antibody Response
    • T-Cell-Mediated Immune Response
    • NK Cells
    • Macrophages, Neutrophils and Mast Cells
    • Complement and Related Defence Molecules
    • Conclusions Concerning the Immune Response to Microorganisms
    • Bibliography
  • Chapter 7. Microbial Strategies in Relation to the Immune Response
    • Induction of Immunological Tolerance
    • Immunosuppression
    • Absence of a Suitable Target for the Immune Response
    • Microbial Presence in Bodily Sites Inaccessible to the Immune Response
    • Induction of Inappropriate Antibody and T-Cell Responses
    • Antibodies Mopped up by Soluble Microbial Antigens
    • Local Interference with Immune Forces
    • Reduced Interferon Induction or Responsiveness
    • Antigenic Variation
    • Bibliography
  • Chapter 8. Mechanisms of Cell and Tissue Damage
    • Infection with No Cell or Tissue Damage
    • Direct Damage by Microorganisms
    • Microbial Toxins
    • Indirect Damage via Inflammation
    • Indirect Damage via the Immune Response (Immunopathology)
    • Other Indirect Mechanisms of Damage
    • Diarrhoea
    • Bibliography
  • Chapter 9. Recovery from Infection
    • Immunological Factors in Recovery
    • Inflammation
    • Complement
    • Interferons
    • Multimechanistic Recovery: An Example
    • Temperature
    • Tissue Repair
    • Resistance to Re-Infection
    • Bibliography
  • Chapter 10. Failure to Eliminate Microbe
    • Latency
    • Persistent Infection with Shedding
    • Epidemiological Significance of Persistent Infection with Shedding
    • Persistent Infection Without Shedding
    • Significance for the Individual of Persistent Infections
    • Conclusions
    • Bibliography
  • Chapter 11. Host and Microbial Factors Influencing Susceptibility
    • Genetic Factors in the Microorganism
    • Genetic Factors in the Host
    • Stress and Hormonal Factors
    • Other Factors
    • Bibliography
  • Chapter 12. Vaccines and How They Work
    • Introduction
    • General Principles
    • Complications and Side Effects of Vaccines
    • Reverse Vaccinology
    • Bibliography
  • Appendix
  • Conclusions
  • Glossary
  • Index
Book details
ISBN: 9780123971883
Page Count: 364
Retail Price : £45.99
  • Krause, Emerging Infections, 1999, 9780124259300, $99.95
  • White, Medical Virology, 4e, 1994, 9780127466422, $72.95
Undergraduate and graduate students in microbiology and immunology, medical students, and others new to the field of microbiology and infectious diseases
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