Basic and Applied Bone Biology,
Edition 1
Edited by David B. Burr and Matthew R. Allen

Publication Date: 12 Aug 2013

This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models.

Key Features

  • Presents an in-depth overview of skeletal biology from the molecular to the organ level
  • Offers "refresher" level content for clinicians or researchers outside their areas of expertise
  • Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology
About the author
Edited by David B. Burr, Professor, Department of Anatomy and Cell Biology, Indiana University School of Medicine; Professor of Biomedical Engineering (IUPUI), and Professor of Biomedical Engineering (Purdue University); Adjunct Professor of Anthropology, Department of Anthropology, IUPUI and Indiana University, Indianapolis, IN, USA and Matthew R. Allen, Assistant Professor, Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
Table of Contents





List of Contributors

Section 1: Basic Bone Biology and Physiology

Chapter 1. Bone Morphology and Organization

The Functions of Bone

Bone is Organized as a Multiscale Material

Bone Composition

The Nanoscale Organization of Bone

The Microstructural Organization of Bone

The Macroscopic Organization of Bone

The Blood Supply and Innervation of Bone

Bone Fluid Compartments

Bone Mass and Bone Quality

Suggested Readings

Chapter 2. Bone Cells




Suggested Readings

Chapter 3. Local Regulation of Bone Cell Function

Overview of Cytokines and Growth Factors and their Receptors

Local Factors that Regulate Osteoclast and Osteoblast Differentiation and Function

Factors that Regulate Osteoclast Differentiation and Function

Factors that Affect Osteoblast Differentiation and Function

Local Factors that Affect Both Osteoclasts and Osteoblasts

Regulation of Bone Cell Differentiation and Function Through Cell-Cell Contact

Local Angiogenic Factors that Regulate Bone Cell Activity

Cell Surface Attachment Molecules

Suggested Readings

Chapter 4. Bone Modeling and Remodeling

Skeletal Development

Bone Modeling

Bone Remodeling

Bone Repair

Effects of Modeling and Remodeling on Bone Structure and Material Properties

Laboratory Assessment of Modeling and Remodeling

Suggested Readings

Section 2: Assessment of Bone Structure and Function

Chapter 5. Skeletal Imaging


Absorptiometry (Photon and X-Ray)

Computed Tomography

Magnetic Resonance Imaging

Positron Emission Tomography


Suggested Readings

Chapter 6. Skeletal Hard Tissue Biomechanics

Introduction to Basic Bone Structure and Function

Fundamentals of Solid Mechanics

Factors Contributing to Whole Bone Mechanical Properties

Suggested Readings

Chapter 7. Techniques in Histomorphometry

Histologic Specimens

Histomorphometric Analysis

Assumptions and Technical Aspects

Histologic Features of Disease and Treatment

Suggested Readings

Chapter 8. Skeletal Genetics: From Gene Identification to Murine Models of Disease

Simple and Complex Traits

Transgenic Technology and the Creation of Novel Research Models

Transgenic Animals and Bone Biology

Suggested Readings

Section 3: Skeletal Adaptation

Chapter 9. Mechanical Adaptation

Wolff’s Law—A Historical Perspective

Components of Strain that May be Osteogenic

Animal Models of Skeletal Mechanotransduction

Rules for Bone Adaptation

The Mechanostat

Cell Sensitivity and Refractory Periods

A Test of Wolff’s Law

Mechanotransduction on a Smaller Scale: Cell Types and their Environment

Fluid Flow in Bone Tissue has Manifold Cellular Effects

Cellular Deformation and Stimulation

What is the Mechanoreceptor?

Coordinating the Biochemical Response to Mechanical Stimulation

Clinical Implications: Reaping the Benefits of Mechanical Loading Effects to Improve Skeletal Health

Important Features of Exercise Regimens Designed to Influence Skeletal Adaptation

Skeletal Benefit of Exercise During Infancy and Childhood

Skeletal Response to Exercise in Adulthood

Suggested Readings

Chapter 10. Fracture Healing


Types of Bone Fracture

Primary and Secondary Repair Mechanisms

Stages of Fracture Repair

Assessment of Fracture Healing

Cellular Events of Fracture Repair

Molecular Regulation of Chondrogenesis and Osteogenesis During Fracture Repair

Local Regulation of Fracture Repair

Systemic Factors in Fracture Repair

Effects of Osteoporosis Drugs on Fracture Healing

Effects of Mechanical and Electrical Stimulation on Fracture Repair

Suggested Readings

Chapter 11. Craniofacial Biology, Orthodontics, and Implants

Craniofacial Skeleton

Orthodontic Tooth Movement

Suture Expansion


Suggested Readings

Section 4: Hormonal and Metabolic Effects on Bone

Chapter 12. Skeletal Growth and Development



Development of Peak Bone Mass

Regulators of Growth

Catch-Up Growth

Fracture Risk in Children

Suggested Readings

Chapter 13. Calcium and Phosphate: Hormonal Regulation and Metabolism

Interplay Among Organ Systems Regulates Calcium and Phosphorus Metabolism

Regulation of Whole Body Calcium Metabolism

Hormones Controlling Calcium Metabolism

Regulation of Whole Body Phosphate Metabolism

Suggested Readings

Chapter 14. Nutrition

Macro- and Micronutrient Roles in Bone Health

When and How Nutrients Influence Bone Mass

Perturbing Calcium Metabolism

Whole Diet Matters

Dietary Bioactives and their Mechanisms

Effects of Obesity and Weight Loss on Bone

Correcting Nutrient Deficiencies Versus Optimizing Intakes

Challenges for Studying Nutrient Interventions

Suggested Readings

Chapter 15. Hormonal Effects on Bone Cells

Introduction: Direct Versus Indirect Effects of Hormones on Bone Cells

Parathyroid Hormone

Sex Steroids


Thyroid Hormone

Somatotropin/Growth Hormone


1,25-Dihydroxyvitamin D3


Suggested Readings

Section 5: Skeletal Disease and Treatment

Chapter 16. Metabolic Bone Diseases


Osteogenesis Imperfecta



Nutritional Rickets/Osteomalacia




Paget Disease of Bone


Suggested Readings

Chapter 17. Pharmaceutical Treatments of Osteoporosis

Calcium and Vitamin D

Anticatabolic Therapies

Anabolic Therapy

Combination Treatments

Emerging Therapies

Treatment Decisions

Suggested Readings


Book details
ISBN: 9780124160156
Page Count: 390
Retail Price : £68.99

Principles of Bone Biology, 3e, Bilezikian, 9780123738844, $344, 1900 pp., 09/2008, AP
Osteoimmunology, Lorenzo, 9780123756701, $99.95, 454 pp., 08/2010, AP
Osteoporosis in Men, 2e, Orwoll, 9780123746023, $180.00, 741 pp., 11/2009, AP


Graduate students, medical fellows/residents, researchers, and academic clinicians in the fields of bone biology, endocrinology, osteology, rheumatology, and dentistry.