Molecules to Medicine with mTOR - Edition 1 - Edited by Kenneth Maiese Elsevier Educate

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Molecules to Medicine with mTOR,

Edition 1 Translating Critical Pathways into Novel Therapeutic Strategies

Edited by Kenneth Maiese

Publication Date: 26 Feb 2016

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Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin.

Key Features

Covers the role of mTOR by internationally recognized expert contributors in the field.
Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels.
Includes analysis of the role of mTOR and in both health and disease.
Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.

About the author

Edited by Kenneth Maiese, Biotechnology and Venture Capital Development, Office of Translational Alliances and Coordination, National Heart, Lung, and Blood Institute; Cellular and Molecular Signaling, New York, NY, United States

ISBN: 9780128027332

Page Count: 472

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Scientists (cell biologists, molecular biologists, pharmacologists, vascular biologists, neuroscientists, etc.), physicians (all disciplines including cardiology, gastroenterology, internal medicine, oncology, neurology, etc.), pharmaceutical industry experts, nutritionists, and students (graduate, medical, postdoctoral, etc.) from multiple backgrounds.

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