The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation.
This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness.
Winner of the 2018 PROSE Award in Clinical Medicine from the Association of American Publishers!
Key Features
- 2018 PROSE Awards - Winner, Award for Clinical Medicine: Association of American Publishers
- Outlines sex-specific differences in normal human function and explains the impact of age, hormones, and environment on the incidence and outcome of illness
- Reflects the latest information about the molecular basis of the sexual dimorphism in human physiology and the experience of disease
- Reviews the implications of our ever-improving ability to describe the genetic basis of vulnerability to disease and our capacity to alter the genome itself
- Illustrates the importance of new NIH guidelines that urge the inclusion of sex as a variable in research protocols
1. Normal and variant sex development
Olaf Hiort
2. Gender Diagnoses
Jack Drescher
3. Gender Identity in Disorders of Sex Development
Leanna W. Mah, Yvonne Y. Chan, and Jennifer H. Yang
4. Female sexual function: the role of animal models in assessing female sexual dysfunction
Lesley Marson and Ursula Wesselman
5. Fertility Treatment and Preservation in Transgender Men and Women
Dov Feldberg
6. Standards of Care for the Health of Transsexual, Transgender and Gender-Nonconforming People: An Introduction
Eli Coleman
7. Sex-dependent and -independent Mechanisms in External Genitalia Development
Congxing Lin and Liang Ma
8. The Transsexual Adult
Swaytha Yalamanchi, Betiel Fesseha, Adrian Dobs
9. Sexual and gender minority individuals in health care: strategies to include sexual orientation and gender identity in health professions education
Alexandra Muller
10. Sex Influences Exist at All Levels of Human Brain Function
Larry Cahill
11. Sex differences in the brain: Focus on developmental mechanisms
Margaret M McCarthy
12. Sexual dimorphisms in the nervous system of the nematode Caenorhabditis elegans
Meital Oren-Suissa and Oliver Hobert
13. Oxytocin and Brain Plasticity
Robert C. Froemke and Ioana Carcea
14. Emotion and Gender-specific neural processing in men and women
Sarah Whittle, Julian G. Simmons and Nicholas B. Allen
15. Behind the Mask: the experience of assessment, diagnosis and living with autism for girls and young women
Siobhan Tierney and Jan Burns
16. The significance of gender in perinatal medicine
Kristie Hadley, Eyal Sheiner
17. Intrauterine Development of Sex Differences – Fetal Programming
Marek Glezerman
18. Battle of the sexes: How the selection of spermatozoa in the female reproductive tract manipulates the sex ratio of offspring
Lisa M. Thurston, William V. Holt and Alireza Fazeli
19. All Cells have a sex: Studies of sex chromosome function at the cellular level
Neil A. Bradbury
20. Sex-specific implications of exposure to an adverse intrauterine environment
Catherine E. M. Aiken
21. Immune response – Impact of biological sex and gender
Sabine Oertelt-Prigione
22. Geoepidemiology and the Impact of Sex on Autoimmune Diseases
Ana Lleo
23. Gender and gene regulation in human immunity
Michelle R. Longmire and Howard Chang
24. Sex and gender specific aspects - from cells to cardiovascular disease
Vera Regitz-Zagrosek
25. Estrogen: Impact on Cardiomyocytes and the Heart
Jin Kyung Kim
26. The Sexually Dimorphic Characteristics of the Pathophysiology and Treatment of Atrial Fibrillation
Uma Avula, Meghana Noonavath and Elaine Wan
27. Gender Differences in Chronic Obstructive Pulmonary Disease- Current Knowledge and Deficits
Santosh K. Nepal and Shambhu Aryal
28. Cancer: Gender differences at the molecular level
Mehmet Tevfik Dorak
29. An Updated Overview of the Gender-Specific Response to Infection
Tiffany Guess and Erin McClelland
30. Gender Based Differences in Mortality in Indian Children Aged 5 to 14 years
Claire K. Nguyen and Shaun K. Morris
31. Consideration of biological sex in translating regenerative stem cell therapies
Galina Shapiro, Gadi Pelled, Dan Gazit
32. Adipose-derived Stem Cells in Regenerative Medicine
Hiroshi Mizuno, Morikuni Tobita, Rei Ogawa, Hakan Orbay, Juri Fujimura, Shimpei Ono, Natsuko Kakudo, Kenji Kusumoto and Hiko Hyakusoku
33. Sex, Gender and Pain
Roger B. Fillingim
34. Sex and gender differences in trauma victims presenting for treatment
Dorte M. Christiansen
35. Women Do Worse Than Men – Gender-Specific Differences in Burn Patients
Ines Ana Ederer, Florian Hackl and Reinhard Pauzenberger
36. Exercise physiology in Men & Women
Anne-Marie Lundsgaard, Andreas M. Fritzen and Bente Kiens
37. Musculoskeletal complaints in male and female instrumental musicians
Laura M. Kok, B.M.A. Huisstede and Rob G.H.H. Nelissen
38. Nutritional Genomics and Biological Sex
Jose M. Ordovas
39. Microbiome: Impact of gender on function & characteristics of gut microbiome
Veena Taneja
40. Sex and Gender Differences in Sleep Disorders: An Overview
Fidaa Shaib and Hrayr Attarian
41. Gender differences in bladder and kidney cancers
Stephan M. Korn and Shahrokh F. Shariat
42. The complex challenge of blood pressure regulation: influences of sex and aging on sympathetic mechanisms
Emma C. Hart and Nisha Charkoudian
43. Gender at the Interface of Renal Aging: Physiological and Pathological Perspectives
Davide Bolignano and Anna Pisano
44. Gender differences in mobility of elderly: Measurements and interventions to improve mobility
Emil Jovanov, Karen H.Frith, Priyanka Madhushri, Amy Hunter, Sharon Saunderson Coffey, Aleksandar Milenkovic
45. Personalized Medicine in Space Flight, Part I: The Space Context and Standard Clinical Approaches
Schmidt MA, Goodwin TJ, Cuttino M
46. Personalized Medicine in Space Flight, Part II: Personalized Precision Medicine Approaches
Schmidt MA, Goodwin TJ, Cuttino M
47. Robots and Gender
Tatsuya Nomura
48. Cyborgs: Understanding and Mutual Treatment
Kevin Warwick
49. Personalized Medicine and Challenges in Research and Clinical Implementation
Susanne B. Haga
50. Biological Sex Differences in Humans and their Importance in Pharmaceutical Drug Discovery and Development
Ibis Sánchez-Serrano
- Goldman, Women and Health, 9780123849786, AP, Dec 2012, 1600 pp., $199.95
- Coulston, Nutrition in the Prevention and Treatment of Disease, 3e, 9780123918840, AP, Oct 2012, $99.95
- Marcus, Osteoporosis, 4e, 9780124158535, AP, Jun 2013, 2,068 pp., $450.00
Researchers, practitioners, and graduate students in physiology, cardiology, neurology, respiratory medicine, gastroenterology, endocrinology, oncology, immunology, and emergency medicine who research and/or teach gender-specific medicine or sex-based biology
