Biometals in Neurodegenerative Diseases - Edition 1 - Edited by Anthony R. White, Michael Aschner, Lucio G. Costa and Ashley I. Bush Elsevier Inspection Copies

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Biometals in Neurodegenerative Diseases,

Edition 1 Mechanisms and Therapeutics

Edited by Anthony R. White, Michael Aschner, Lucio G. Costa and Ashley I. Bush

Publication Date: 28 Apr 2017

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Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders.

This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases.

Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.

Key Features

Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets
Written for academic researchers, clinicians, and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology
Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

About the author

Edited by Anthony R. White, University of Melbourne, Victoria, Australia ; Michael Aschner, Professor, Department of Molecular Pharmacology, Albert Einstein College of Medicine, NY, USA; Lucio G. Costa, Professor of Toxicology, University of Washington, Seattle, WA, USA and Ashley I. Bush, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia

Chapter 1: Biometals and Alzheimer’s Disease
Alexandra I. Mot and Peter J. Crouch

Abstract
Introduction
The Role of Copper in AD
The Role of Zinc in AD
The Role of Iron in AD
Therapeutic Targeting of Biometals in AD
Conclusions

Chapter 2: Copper in Alzheimer’s Disease
Rosanna Squitti, Mariacarla Ventriglia, Mariacristina Siotto and Carlo Salustri

Abstract
Introduction
The Physiology of Copper
Copper Toxicity
Conclusions

Chapter 3: The Role of Selenium in Neurodegenerative Diseases
Bárbara R. Cardoso, Dominic J. Hare and Ashley I. Bush

Abstract
Introduction
Selenoproteins and the Selenoproteome
Selenium and Alzheimer’s Disease
Parkinson’s Disease
Other Neurodegenerative Diseases
Conclusions

Chapter 4: Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response?
Anne M. Nixon and James R. Connor

Abstract
Iron
Hemochromatosis
HFE
Macrophages
HFE Animal Models
Conclusions

Chapter 5: Chemical Elements and Oxidative Status in Neuroinflammation
Michela Ferraldeschi, Silvia Romano, Maria Chiara Buscarinu, Arianna Fornasiero, Rosella Mechelli, Benedetta Cerasoli, Anna Pino, Sonia Brescianini, Carlo Mattei, Maria Antonia Stazi, Alessandro Alimonti, Marco Salvetti and Giovanni Ristori Sr.

Abstract
Introduction
Metal-Induced Neurotoxicity and Multiple Sclerosis
Metals and Oxidative Status in Multiple Sclerosis
Metals and Oxidative Status in Clinically Isolated Syndromes
Conclusions

Chapter 6: Metals and Neuroinflammation
Stephen C. Bondy

Abstract
Introduction
Mechanisms by Which Metal Elements Can Incite Immune Activity
The Relation Between Reactive Oxygen and Nitrogen Species and Inflammation
Conclusions

Chapter 7: Metals and Prions: Twenty Years of Mining the Awe
David R. Brown

Abstract
Prion Diseases
Prion Protein
Prion Protein Function
Copper and PrP
Zinc and PrP
Iron and PrP
Manganese and PrP
Metals in Prion Disease
Chelation Therapy and Prion Disease
Conclusions

Chapter 8: Manganese and Neurodegeneration
Dinamene Marques dos Santos, Michael Aschner and Ana Paula Marreilha dos Santos

Abstract
Background
Mn Essentiality and Metabolic Functions
Mn Biokinetics and Homeostatic Control
Neurotoxicology of Mn
Biomonitoring of Mn in Patients Undergoing PN
Conclusions
Acknowledgment

Chapter 9: Zinc in Autism
Stefanie Grabrucker and Andreas Grabrucker

Abstract
Introduction
Zinc Signaling in Autism
Therapeutic Strategies in Autism Based on Biometals
Conclusions

Chapter 10: Metals and Motor Neuron Disease
Per M. Roos

Abstract
List of Abbreviations
Introduction
Metal Exposure
Metals in ALS Cerebrospinal Fluid
Metals in ALS
Protection by Metallothionein
Metal Distribution in ALS
Genetic Aspects
Concluding Remarks

Chapter 11: Metals and Lysosomal Storage Disorders
H. Konttinen, K. Lejavová, T. Malm and Katja Kanninen

Abstract
Introduction
Common Pathological Features of Lysosomal Storage Disorders
Description of Most Common Neurodegenerative LSDs Associated with Biometal Imbalance
Function and Regulation of Biometals
Role of Biometals and Biometal Binding Proteins in LSDs
Targeting Metals to Treat Disease

Chapter 12: Developmental Exposure to Metals and its Contribution to Age-Related Neurodegeneration
Lucio G. Costa

Abstract
Introduction
Developmental Exposure to Toxicants and Late Effects
Developmental Lead Exposure and Alzheimer's Disease
Developmental Arsenic Exposure and Alzheimer's Disease
Conclusions and Future Perspectives
Acknowledgment

Chapter 13: Metal Biology Associated with Huntington’s Disease
Terry Jo Vetters Bichell, Timothy C. Halbesma, K. Grace Tipps and Aaron Bowman

Abstract
Introduction
The Epidemiology of HD
The Symptoms of HD
The Neuropathology of HD
Biological Function of Wild-type and Pathogenic HTT Proteins
Autophagy and Metals in Huntington’s Disease
Exosomes and Metal in Huntington’s Disease
Environmental Factors Impacting HD
Metals in HD
Iron in HD
Copper in HD
Calcium in HD
Manganese in HD
Manganese Deposition: Brain Regions, Cell Types, and Cellular Organelles
Manganese Dyshomeostasis in HD
Mn-Dependent and Mn-Utilizing Enzymes
Intracellular pH and Metal Biology in HD
Metal-Related Clinical Interventions in HD
Conclusions and Future Directions

Chapter 14: Metal-Binding to Amyloid-ß Peptide: Coordination, Aggregation, and Reactive Oxygen Species Production
Melisa del Barrio, Valentina Borghesani, Christelle Hureau and Peter Faller

Abstract
Introduction
Structure of the Metal-Aß Complexes
Affinity of Metals to Aß
Aggregation
Reactive Oxygen Species Induced Oxidative Stress
Conclusions
Acknowledgments

Chapter 15: Metals and Mitochondria in Neurodegeneration
Germán Plascencia-Villa, Miguel José Yacamán and George Perry

Abstract
Introduction
Iron Dyshomeostasis
Copper Dislocation
Zinc Deficiency
Mitochondrial Dysfunction
Conclusions
Acknowledgments

Chapter 16: Metal Transporters in Neurodegeneration
Hong Jiang

Abstract
Iron Transporters and Neurodegeneration
Zinc Transporters and Neurodegeneration
Copper Transporters and Neurodegeneration
Manganese Transporters and Neurodegeneration
Magnesium Transporters and Neurodegeneration
Aluminum Transporters and Neurodegeneration
Conclusions

Chapter 17: Metal Imaging in the Brain
David C. Dorman

Abstract
Introduction
Introduction to MRI Physics
MRI Contrast Agents
Gadolinium
Iron
Copper
Manganese

Chapter 18: Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases
A. Ramírez Muñoz, M. A. Greenough, Ashley I. Bush and C. M. Opazo

Abstract
Introduction
Metalloregulation of the Ubiquitin Proteasome System: Implication in Neurodegenerative Diseases
Metals as Mediators of Autophagy-Lysosomal Response
Conclusions
Acknowledgments

Chapter 19: Metals and Autophagy in Neurotoxicity
Peng Su, Michael Aschner, Jingyuan Chen and Wenjing Luo

Abstract
Introduction
Part 1 Metal-Related Neurotoxicity and Neurodegenerative Diseases
Part 2 Autophagy in Metal Neurotoxicity
Conclusions
Acknowledgments

Chapter 20: An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases
Frank W. Lewis and David Tétard

Abstract
Introduction
Parent Metal Chelators
Multifunctional Metal Chelators
Conclusions

Chapter 21: Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases
Katja Kanninen and Anthony R. White

Abstract
Background
Biometals
Abnormal Biometal Levels and Distribution Underlie Most Forms of Neurodegeneration
Abnormal Metalloprotein Function Underlying Neurodegenerative Diseases
Neurodegenerative Diseases Caused by Mutation in Metalloproteins
Neurodegenerative Diseases Associated With Abnormal Metalloprotein Function
Neurodegenerative Diseases Involving Biometal Changes but Without a Clearly Identified Role for Metalloprotein Abnormities
Neurodegenerative Diseases Where No Major Role for Biometals or Metalloproteins Has Yet Been Identified
Conclusions

ISBN: 9780128045626

Page Count: 462

Retail Price : £118.00

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Academic researchers, clinicians, and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology, and neurotoxicology

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