Medical Image Analysis,
Edition 1
Edited by Alejandro Frangi, Jerry Prince and Milan Sonka

Publication Date: 27 Sep 2023
Medical imaging is increasingly at the base of many breakthroughs in biomedical sciences, becoming a fundamental enabling technology of biomedical scientific progress. Medical Image Analysis presents practical knowledge on medical image computing and analysis and is written by top educators and experts in the field. This text is a modern, practical, broad, and self-contained reference that conveys a mix of essential methodological concepts within different medical domains, reflecting the nature of the discipline today, making it suitable as a course text and a self-learning resource.

Key Features

  • An authoritative presentation of key concepts and methods from experts in the field
  • Sections clearly explaining key methodological principles within relevant medical applications
  • Self-contained chapters enable the text to be used on courses with differing structures
  • A representative selection of modern topics and techniques in medical image computing
  • Focus on medical image computing as an enabling technology to tackle unmet clinical needs
  • Presentation of traditional and machine learning approaches to medical image computing
About the author
Edited by Alejandro Frangi, Professor of Biomedical Image Computing, University of Sheffield, UK; Jerry Prince, Professor of Electrical and Computer Engineering, Johns Hopkins University, USA and Milan Sonka, Professor of Electrical and Computer Engineering, The University of Iowa, USA
Table of Contents

PART I Introductory topics
1. Medical imaging modalities
Mathias Unberath and Andreas Maier
1.1 Introduction
1.2 Image quality
1.3 Modalities and contrast mechanisms
1.4 Clinical scenarios
1.5 Exercises

2. Mathematical preliminaries
Carlos Alberola-López and Alejandro F. Frangi
2.1 Introduction
2.2 Imaging: definitions, quality and similarity measures
2.3 Vector and matrix theory results
2.4 Linear processing and transformed domains
2.5 Calculus
2.6 Notions on shapes
2.7 Exercises

3. Regression and classification
Thomas Moreau and Demian Wassermann
3.1 Introduction
3.2 Multidimensional linear regression
3.3 Treating non-linear problems with linear models
3.4 Exercises

4. Estimation and inference
Gonzalo Vegas Sánchez-Ferrero and Carlos Alberola-López
4.1 Introduction: what is estimation?
4.2 Sampling distributions
4.3 Estimation. Data-based methods
4.4 A working example
4.5 Estimation. Bayesian methods
4.6 Monte Carlo methods
4.7 Exercises

PART II Image representation and processing
5. Image representation and 2D signal processing
Santiago Aja-Fernández, Gabriel Ramos-Llordén, and Paul A. Yushkevich
5.1 Image representation
5.2 Images as 2D signals
5.3 Frequency representation of 2D signals
5.4 Image sampling
5.5 Image interpolation
5.6 Image quantization
5.7 Further reading
5.8 Exercises

6. Image filtering: enhancement and restoration
Santiago Aja-Fernández, Ariel H. Curiale, and Jerry L. Prince
6.1 Medical imaging filtering
6.2 Point-to-point operations
6.3 Spatial operations
6.4 Operations in the transformdomain
6.5 Model-based filtering: image restoration
6.6 Further reading
6.7 Exercises

7. Multiscale and multiresolution analysis
Jon Sporring
7.1 Introduction
7.2 The image pyramid
7.3 The Gaussian scale-space
7.4 Properties of the Gaussian scale-space
7.5 Scale selection
7.6 The scale-space histogram
7.7 Exercises

PART III Medical image segmentation
8. Statistical shape models
Tim Cootes
8.1 Introduction
8.2 Representing structures with points
8.3 Comparing shapes
8.4 Aligning two shapes
8.5 Aligning a set of shapes
8.6 Building shape models
8.7 Statistical models of texture
8.8 Combined models of appearance (shape and texture)
8.9 Image search
8.10 Exhaustive search
8.11 Alternating approaches
8.12 Constrained local models
8.13 3D models
8.14 Recapitulation
8.15 Exercises

9. Segmentation by deformable models
Jerry L. Prince
9.1 Introduction
9.2 Boundary evolution
9.3 Forces and speed functions
9.4 Numerical implementation
9.5 Other considerations
9.6 Recapitulation
9.7 Exercises

10. Graph cut-based segmentation
Jens Petersen, Ipek Oguz, and Marleen de Bruijne
10.1 Introduction
10.2 Graph theory
10.3 Modeling image segmentation using Markov random fields
10.4 Energy function, image term, and regularization term
10.5 Graph optimization and necessary conditions
10.6 Interactive segmentation
10.7 More than two labels
10.8 Recapitulation
10.9 Exercises

PART IV Medical image registration
11. Points and surface registration
Shan Cong and Li Shen
11.1 Introduction
11.2 Points registration
11.3 Surface registration
11.4 Summary
11.5 Exercises

12. Graph matching and registration
Aristeidis Sotiras, Mattias Heinrich, Julia Schnabel, and Nikos Paragios
12.1 Introduction
12.2 Graph-based image registration
12.3 Exercises

13. Parametric volumetric registration
Paul A. Yushkevich, Miaomiao Zhang, and Jon Sporring
13.1 Introduction to volumetric registration
13.2 Mathematical concepts
13.3 Parametric volumetric registration
13.4 Exercises

14. Non-parametric volumetric registration
Paul A. Yushkevich and Miaomiao Zhang
14.1 Introduction
14.2 Mathematical concepts
14.3 Optical flow and related non-parametric methods
14.4 Large deformation diffeomorphic metric mapping
14.5 Exercises

15. Image mosaicking
Sophia Bano and Danail Stoyanov
15.1 Introduction
15.2 Motion models
15.3 Matching
15.4 Clinical applications
15.5 Recapitulation
15.6 Exercises

PART V Machine learning in medical image analysis
16. Deep learning fundamentals
Nishant Ravikumar, Arezoo Zakeri, Yan Xia, and Alejandro F. Frangi
16.1 Introduction
16.2 Learning as optimization
16.3 Inductive bias, invariance, and equivariance
16.4 Recapitulation
16.5 Further reading
16.6 Exercises

17. Deep learning for vision and representation learning
Arezoo Zakeri, Yan Xia, Nishant Ravikumar, and Alejandro F. Frangi
17.1 Introduction
17.2 Convolutional neural networks
17.3 Deep representation learning
17.4 Recapitulation
17.5 Further reading
17.6 Exercises

18. Deep learning medical image segmentation
Sean Mullan, Lichun Zhang, Honghai Zhang, and Milan Sonka
18.1 Introduction
18.2 Convolution-based deep learning segmentation
18.3 Transformer-based deep learning segmentation
18.4 Hybrid deep learning segmentation
18.5 Training efficiency
18.6 Explainability
18.7 Case study
18.8 Recapitulation
18.9 Further reading
18.10 Exercises

19. Machine learning in image registration
Bob D. de Vos, Hessam Sokooti, Marius Staring, and Ivana Išgum
19.1 Introduction
19.2 Image registration with deep learning
19.3 Deep neural network architecture
19.4 Supervised image registration
19.5 Unsupervised image registration
19.6 Recapitulation
19.7 Exercises

PART VI Advanced topics in medical image analysis
20. Motion and deformation recovery and analysis
James S. Duncan and Lawrence H. Staib
20.1 Introduction
20.2 The unmet clinical need
20.3 Image-centric flow fields: Eulerian analysis
20.4 Object-centric, locally derived flow fields: Lagrangian Analysis
20.5 Multiframe analysis: Kalman filters, particle tracking
20.6 Advanced strategies: model-based analysis and data-driven deep learning
20.7 Evaluation
20.8 Recapitulation
20.9 Exercises

21. Imaging Genetics
Marco Lorenzi and Andre Altmann
21.1 Introduction
21.2 Genome-wide association studies
21.3 Multivariate approaches to imaging genetics
21.4 Exercises

PART VII Large-scale databases
22. Detection and quantitative enumeration of objects from large images
Cheng Lu, Simon Graham, Nasir Rajpoot, and Anant Madabhushi
22.1 Introduction
22.2 Classical image analysis methods
22.3 Learning from data
22.4 Detection and counting of mitotic cells using Bayesian modeling and classical image processing
22.5 Detection and counting of nuclei using deep learning
22.6 Recapitulation
22.7 Exercises

23. Image retrieval in big image data
Sailesh Conjeti, Stefanie Demirci, and Vincent Christlein
23.1 Introduction
23.2 Global image descriptors for image retrieval
23.3 Deep learning-based image retrieval
23.4 Efficient indexing strategies
23.5 Exercises

PART VIII Evaluation in medical image analysis
24. Assessment of image computing methods
Ipek Oguz, Melissa Martin, and Russell T. Shinohara
24.1 The fundamental methodological concept
24.2 Introduction
24.3 Evaluation for classification tasks
24.4 Learning and validation
24.5 Evaluation for segmentation tasks
24.6 Evaluation of registration tasks
24.7 Intra-rater and inter-rater comparisons
24.8 Recapitulation
24.9 Exercises

Book details
ISBN: 9780128136577
Page Count: 698
Retail Price : £108.00
9780123869081; 9780123739049; 9780128025819
Graduate students and biomedical engineers from both industry and academia who have basic image processing knowledge. Medical doctors and biologists with no background in image processing will also find methods and software tools for analyzing medical images