New Edition
Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease,
Edition 6 Volume 1
Edited by Roger N. Rosenberg and Juan M. Pascual

Publication Date: 23 Jun 2020

Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume One, provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling.

Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format.

Key Features

  • Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease
  • Provides a detailed introduction on both the clinical and basic research implications of molecular and genetics surrounding the brain
  • Includes new chapters on molecular genomics, CRISPR and the most recent updates in molecular genetics
About the author
Edited by Roger N. Rosenberg, Abe (Brunky), Morris and William Zale Distinguished Chair in Neurology, Professor of Neurology and Neurotherapeutics, Founding Director, Alzheimer’s Disease Center Head, Section on Memory and Behavioral Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Juan M. Pascual, Dept Neurology and Neurotherapeutics, Physiology and Pediatrics and McDermott Ctr for Human Growth and Dev/Ctr for Human Genetics, Univ of Texas Southwestern Medical Ctr, Dallas, TX, USA
Table of Contents
SECTION I. GENERAL CONCEPTS AND TOOLS1. Mendelian, non-Mendelian, multigenic inheritance, and epigenetics2. Precision medicine in neurology 3. Epigenomics of neurological disorders4. GenotypeSECTION II. NEUROLOGIC DISEASES18. Cerebral malformations19. Global developmental delay and intellectual disability20. Alzheimer’s disease and down syndrome21. An overview of Rett syndrome22. Fragile X clinical features and neurobiology23. Neurological evaluation and management of autism spectrum disorder24. Angelman syndrome25. Prion diseasesSECTION III. NEUROMETABOLIC DISORDERSSub-Section: Mitochondrial Disorders26. The mitochondrial genome27. Mitochondrial disorders due to mutations in the mitochondrial genome28. Mitochondrial disorders due to mutations in the nuclear genome29. Pyruvate dehydrogenase, pyruvate carboxylase, Krebs cycle, and mitochondrial transport disordersSub-Section: Lysosomal Disorders30. Gaucher disease—neuronopathic forms31. The Niemann-Pick diseases32. GM2-gangliosidoses33. Metachromatic leukodystrophy and multiple sulfatase deficiency34. Krabbe disease: globoid cell leukodystrophy35. The mucopolysaccharidoses36. The mucolipidoses37. Disorders of glycoprotein degradation: sialidosis, fucosidosis, a-mannosidosis, ß-mannosidosis, and aspartylglycosaminuria38. ß-Galactosidase deficiency: GM1 gangliosidosis, Morquio B disease, and galactosialidosis39. Acid ceramidase deficiency: Farberlipogranulomatosis, spinal muscular atrophy associated with progressive myoclonic epilepsy and peripheral osteolysis40. Wolman disease41. Lysosomal membrane disorders: lysosome associated membrane protein-2 deficiency (Danon disease)42. Fabry disease: a-galactosidase A deficiency43. Schindler disease: deficient a-Nacetylgalactosaminidase activitySub-Section: Metal Metabolism Disorders44. Wilson disease45. Menkes disease and other ATP7A disorders46. Neurodegeneration with brain iron accumulation47. Pantothenate kinase-associated neurodegeneration48. Disorders of manganese transport49. AceruloplasminemiaSub-Section: Vitamin Disorders50. Genetic and dietary influences on life span51. Vitamins: cobalamin and folate52. Inherited biotin-responsive disorders53. Disorders of pyridoxine metabolismSub-Section: Lipid Metabolism Disorders54. Disorders of lipid metabolism55. Lipoprotein disorders56. Cerebrotendinous xanthomatosisSub-Section: Other Metabolic Disorders57. Organic acid disorders 58. Glycogen and polyglucosan storage diseases59. Disorders of galactose metabolism60. Inborn errors of amino acid metabolism phenylketonuria and disorders of biopterin metabolism61. Urea cycle disorders62. Glucose transporter type I deficiency and other glucose flux disorders63. Maple syrup urine disease: biochemical, clinical and therapeutic considerations64. Congenital disorders of N-linked glycosylation65. Disorders of glutathione metabolism66. Canavan disease67. Neurotransmitter disorders69. Purines and pyrimidines70. The acute porphyrias
Book details
ISBN: 9780128139554
Page Count: 1012
Retail Price : £157.00

9780124051959; 9780123982704; 9780123865250; 9780128030585


Clinical neurologists, psychiatrists, psychologists,neuroscience researchers, clinical neurology researchers, general medical practitioners, and genetic and molecular biologists with an interest in neurogenetics