Nervous System Drug Delivery,
Edition 1 Principles and Practice
Edited by Russell R. Lonser, MD, Malisa Sarntinoranont and Kristof Bankiewicz

Publication Date: 25 Jun 2019

Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques.

Key Features

  • Offers an up-to-date, comprehensive resource on drug delivery to the nervous system
  • Provides a bridge for understanding across nervous system delivery-related physiology, drug delivery principles. and the methodologies that underlie the various methods of drug distribution (with clinical application)
  • Written for a broad audience of researchers, clinicians and advanced graduate students in neuroscience, neurology, neurosurgery, pharmacology, radiology and psychiatry
About the author
Edited by Russell R. Lonser, MD, Professor and Chair, Department of Neurological Surgery, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA ; Malisa Sarntinoranont, Associate Professor, Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida, USA and Kristof Bankiewicz, Kinetics Foundation Chair in Translational Research and Professor in Residence of Neurological Surgery; Principal Investigator, Brain Tumor Center and the Movement Disorders Research Program at the University of California, San Francisco, San Francisco, California, USA
Table of Contents

Section I. Physiology of Nervous System Drug Delivery
1. Fundamentals of Brain–Barrier Anatomy and Global Functions
2. Blood-Brain Barrier in Disease States
3. Pharmacokinetics of Systemic Drug Delivery
4. Pharmacokinetics of Drug Delivery Past the Blood-Brain Barrier
5. Anatomy and Physiology of Cerebrospinal fluid Dynamics
6. Pharmacokinetics of Polymeric Drug Delivery
7. Pharmacokinetic Models of Convection-Enhanced Drug Delivery
8. Mechanisms and Clinical Applications of Stem Cell Therapy

Section II. Nervous System Drug Delivery Techniques
9. Intravenous and Intravascular Drug Delivery
10. Blood-Brain Barrier Disruption
11. Ultrasonic Methods
12. Nanoparticles for Brain Tumor Delivery
13. Solute Transport in the Cerebrospinal Fluid: Physiology and Practical Implications
14. Drug-impregnated Polymer Delivery 
15. Immunomodulatory Methods
16. Convection-Enhanced Drug Delivery in the Central Nervous System
17. Stem Cell Transplantation for Neurological Disease: Technical Considerations and Delivery Devices
18. CRISPR–Cas Gene Editing for Neurological Disease

Section III. Clinical Application of Nervous System Drug Delivery
19. Drug and Disease-Specific Paradigms for Drug Delivery to the Central Nervous System
20. Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Brain Tumors
21. Clinical Methods of Nervous System Drug Delivery for Tumors
22. Delivery Methods for Treatment of Genetic Disorders
23. Direct Convective of Nervous System Drug Delivery for Patients with Neurodegenerative Disorders
24. Central Nervous System Drug Delivery after Ischemic or Hemorrhagic Stroke
25. Intrathecal Drug Delivery for Cancer Pain

Book details
ISBN: 9780128139974
Page Count: 556
Retail Price : £127.00
  • Aminoff, Aminoff’s Neurology and General Medicine, 5e, Apr 2014, 9780124077102, $275.00
  • Kulkarni, Handbook of Non-invasive Drug Delivery Systems, Dec 2009, 9780815520252, $280.00
  • Rahman, The Brain as a Drug Target, Jan 2011, 9780123855060, $156.00

Basic and clinical neuroscientists, neurologists, neurosurgeons, pharmacists, radiologists, psychiatrists, advanced graduate students in neuroscience and pharmacology, and industry researchers