Patterning and Cell Type Specification in the Developing CNS and PNS,
Edition 2 Comprehensive Developmental Neuroscience
Edited by Bin Chen, Kenneth Y. Kwan, John Rubenstein and Pasko Rakic

Publication Date: 03 Jun 2020

Patterning and Cell Type Specification in the Developing CNS and PNS, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents recent advances in genetic, molecular and cellular methods that have generated a massive increase in new information. The book provides a much-needed update to underscore the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neural patterning and cell type specification in the developing central and peripheral nervous systems.

Key Features

  • Features leading experts in various subfields as section editors and article authors
  • Contains articles that are peer reviewed to ensure accuracy, thoroughness and scholarship
  • Covers mechanisms which control regional specification, regulate proliferation of neuronal progenitors, control differentiation and survival of specific neuronal subtypes, and control the development of non-neural cells
About the author
Edited by Bin Chen, Professor of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, USA; Kenneth Y. Kwan, Assistant Professor of Human Genetics and Research Assistant Professor, Molecular and Behavioral Neuroscience Institute, University of Michigan, USA; John Rubenstein, Professor, Department of Psychiatry, University of California, San Francisco, USA and Pasko Rakic, Department of Neuroscience, Yale School of Medicine, USA
Table of Contents


1. Morphogens, Patterning Centers, and their Mechanisms of Action

Edwin Shinichi Monuki

2. Telencephalon Patterning

Shubha Tole and Jean Hébert

3. Area Patterning of the Mammalian Neocortex

Elizabeth A. Grove

4. Patterning of Thalamus

Guillermina López-Bendito

5. Midbrain Patterning: Polarity Formation of the Tectum, Midbrain Regionalization, and Isthmus Organizer

Harukazu Nakamura

6. Cerebellar Patterning

Hitoshi Komuro

7. Spinal Cord Patterning

Catarina Catela

8. The Formation and Maturation of Neuromuscular Junctions

Gregorio Valdez

9. Neural Induction of Embryonic Stem/Induced Pluripotent Stem Cells

Anindita Sarkar, Maria Carol Marchetto and Fred H. Gage

10. Cerebral organoids

Orly Reiner and Eyal Karzburn

11. Formation of gyri and sulci

Katherine Long and Wieland B. Huttner


12. Cell Biology of Neuronal Progenitor Cells

Qin Shen

13. Notch and Neural Development

Joshua J. Breunig

14. bHLH Factors in Neurogenesis and Neuronal Subtype Specification

Jane Johnson

15. The Specification and Generation of Neurons in the Ventral Spinal Cord

Michael Matise and Kamal Sharma

16. Neurogenesis in the Cerebellum

Kathleen J Millen

17. The Generation of Midbrain Dopaminergic Neurons

Sandra Blaess and Siew-Lan Ang

18. Neurogenesis in the Basal Ganglia

Kenneth James Campbell

19. Specification of Cortical Projection Neurons: Transcriptional Mechanisms

Jeffrey D. Macklis

20. The Generation of Cortical Interneurons

Gordon Fishell and Renata Batista-Brito

21. Specification of Retinal Cell Types

Bernadett Bosze, Robert B. Hufnagel and Nadean L. Brown

22. Neurogenesis in the Postnatal VZ-SVZ and the Origin of Interneuron Diversity

Arturo Alvarez-Buylla

23. Neurogenesis in the Damaged Mammalian Brain

Masato Nakafuku

24. Neurogenesis in the Nematode Caenorhabditis elegans

Oliver Hobert

25. Development of the Drosophila melanogaster embryonic CNS: From neuroectoderm to unique neurons and glia

Stefan Thor

26. Neurogenesis in Zebrafish

Laure Bally-Cuif

27. Gene regulatory networks controlling neuronal diversity: epigenetics/lncRNAs/enhancers

Jason T. Lambert, Jessica Haigh and Alex S. Nord

28. Post-transcriptional and translational control of neurogenesis

Debra Silver

29. Human neurogenesis: single cell sequencing and in vitro modeling (cerebral organoids)

Arnold Kriegstein, Aparna Bhaduri and Madeline Andrews


30. ‘Glial’ Biology: Has it Come to the Beginning of the End?

David Rowitch and Arturo Alvarez-Buylla

31. Neural Stem Cells Among Glia

Arnold Kriegstein and Arturo Alvarez-Buylla

32. Structure and Function of Myelinated Axons

Matthew Rasband

33. Mechanisms of Astrocyte Development

Debosmita Sardar, Anna Victoria Molofsky and Benjamin Deneen

34. Specification of Macroglia by Transcription Factors: Oligodendrocytes

Michael Wegner

35. Specification of Macroglia by Transcription Factors: Schwann Cells

John Svaren

36. Signaling Pathways that Regulate Glial Development and Early Migration – Oligodendrocytes

Stephen Fancy and Robert H. Miller

37. Signaling Pathways that Regulate Glial Development and Early Migration – Schwann Cells

Kristjan R. Jessen and Rhona Mirsky

38. Microglia

Astrid E. Cardona, Katerina Akassoglou and Dimitrios Davalos

39. Ependymal cells

Kazunobu Sawamoto and Nathalie Spassky

40. Meninges and Vasculature

Julie Siegenthaler and Samuel Pleasure

41. Neuron–Glial Interactions: Neurotransmitter Signaling to Cells of the Oligodendrocyte Lineage

Dwight Bergles

42. Nonmammalian Model Systems: Zebrafish

Bruce Appel and Kelly Monk

43. Astrocyte-Synapse Interactions and Neural Circuit Regulation

Nicola Allen

Book details
ISBN: 9780128144053
Page Count: 1122
Retail Price : £196.00
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Neuroscience, developmental biology researchers, including stem cells, aging, and diseases. Translational neuroscience researchers
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