Hormones, Fourth Edition provides a report on the field of human hormones viewed in light of our current understanding of cellular and subcellular architecture, along with the molecular details of their modes of action. Comprehensive information about hormone action on canonical and non-canonical signaling pathways at cellular and subcellular level and effects on architecture and function of organ systems are discussed. All chapters in this new edition have been completely updated to cover advances in endocrinology research, which has expanded significantly in the last few years. Vast coverage of hormones not previously covered and newly discovered aspects of hormone action are also included.
This new fourth edition is intended to be used by advanced undergraduates and graduate students in the biological sciences. It will also provide useful background information for health professionals, clinicians and researchers in the field of endocrinology, metabolism and biochemistry.
Key Features
- Includes updates on all chapters
- Covers sleep hormones, growth factors, intestinal hormones, calcium-sensing receptor of parathyroid, and others
- Provides essential basics for advanced undergraduates, graduate students and researchers in the biological sciences, as well as clinical aspects and applications for clinicians
- Presented in separate hormone systems, covering the subcellular mode of action of selected hormones and a detailed understanding of their human anatomy and physiology
- Hormone Introduction
- Overview of Hormones
- Hormone Receptors
- Mechanisms of Hormone Action
- Clinical Aspects
- Further Reading
- Steroid Hormones: Chemistry, Biosynthesis, and Metabolism
- Introduction
- Chemistry of Steroids
- Biosynthesis of Steroids
- Serum Binding Proteins for Steroid Hormones
- Further Reading
- The Hypothalamus and Anterior Pituitary
- Introduction
- Anatomical Relationships
- Structure, Synthesis, Secretion and Target Cells of the Hypothalamic Releasing Hormones
- Chemisrty of the Anterior Pituitary Hormones
- Regulation and Biological Actions of Growth Hormone and Prolactin
- Clinical Aspects
- Further Reading
- Posterior Pituitary Hormones
- Introduction
- Anatomony of the Posterior Pituitary
- Structure, Synthesis, Secretion and Target Cells of the Posterior Pituitary Hormones
- Biological Actions of Arginine Vasopressin (AVP)
- Biological Actions of Oxytocin
- Clinical Aspects
- Further Reading
- New Content: effects of hormones on antioxidation
- New Content: discussion of thyrostimulin
- New Content: gene therapy for hormonal diseases, e.g. growth hormone
- Thyroid Hormones
- Introduction
- Anatomy of the Thyroid Gland
- Chemistry of the Thyroid Hormones
- Synthesis and Secretion of Thyroid Hormones
- Regulation of Thyroid Hormone Secretion
- Biological Actions of T3
- Clinical Aspects
- Further Reading
- New content: elaboration of new aspects of vasopressin and oxytocin
- Pancreatic Hormones: Insulin and Glucagon
- Introduction
- Anatomical, Morphological, and Physiological Relationships
- Chemistry, Biochemistry, and Biological Activities of the Pancreatic Hormones
- Clinical Aspects
- Further Reading
- New content: description other hormones in the Islets of Langerhans
- Gastrointestinal Hormones
- Introduction
- Anatomical and Physiological Relationships
- Biochemical Properties and Molecular Actions
- Clinical Aspects
- Further Reading
- New content: discussion of new hormones
- Eicosanoids
- Introduction
- Structure and Nomenclature of Eicosanoids
- Synthesis and Inactivation of Eicosanoids
- Eicosanoid Receptors and Signaling
- Examples of Biological Actions of Prostaglandins
- Clinical Aspects
- Further Reading
- Calcium-Regulating Hormones: Vitamin D, Parathyroid Hormone, Calcitonin & Fibroblast Growth Factor-23
- Introduction
- Anatomical and Physiological Relationships
- Chemistry and Biochemistry
- Biology and Molecular Actions
- Clinical Aspects
- Further Reading
- New content: discussion about calcium-sensing receptor of the parathyroid gland
- New content: coverage of hyperparathyroidism
- New content: discussion of klotho will be added
- Adrenal Corticoids
- Introduction
- Anatomy
- Biochemistry and Biosynthesis of Adrenal Steroids and Testosterone Steroids
- Biological and Molecular Actions of Glucocorticoids
- Clinical Aspects
- Further Reading
- New content: action of Atrionatriuretic Hormone on adrenal cortex
- New content: discussion of apoptosis will be broadened
- New content: description of effects of steroid hormones on ion channels
- Hormones of the Adrenal Medulla
- Introduction
- Anatomical and Physiological Relationships
- Chemistry and Biochemistry of the Catecholamines
- Biological Actions of Catecholamines
- Clinical Aspects
- Further Reading
- New content: discussion of leucine- and tyrosine-enkephalins
- Androgens
- Introduction
- Anatomy of the Male Reproductive System
- Chemistry and Metabolism of Androgens
- Regulation of Androgen Production
- Biological Responses to Androgens
- Clinical Aspects
- Further Reading
- Estrogens and Progestins
- Introduction
- Anatomy of the Female Reproductive System
- Chemistry and Metabolism of Female Steroid Hormones
- Hypothalamic-Pituitary-Ovary Axis
- Biological Responses to Female Sex Steroids
- Clinical Aspects
- Further Reading
- Hormones of Pregnancy, Parturition and Lactation
- Introduction
- Anatomical Relationships and the Beginning of Pregnancy
- Chemistry, Biochemistry, and Activity of the Hormones of Pregnancy
- Parturition
- Lactation
- Clinical Aspects
- Further Reading
- Hormones Related to the Kidney and Cardiovascular System
- Introduction
- Anatomical, Morphological, and Physiological Relationships
- Homeostasis of Fluid, Electrolytes, and Blood Pressure
- Hormones and Blood Cell Production
- Clinical Aspects
- Further Reading
- The Pineal Gland
- Introduction
- Anatomical Features of the Pineal Gland
- Synthesis and Secretion of Melatonin
- Biological Actions of melatonin
- Clinical Aspects
- Further Reading
- New content: sleep hormones (orexins/hypocretins)
- Growth Factors
- Introduction
- Epidermal Growth Factor
- Fibroblast Growth Factor Family
- Platelet Derived Growth Factors
- Insulin-Like Growth Factors
- Transforming Growth Factor ß
- Clinical Aspects
- Further Reading
- New content: discussion on tumor necrosis factor
9780128113714; 9780128138144; 9780128041697; 9780323555969; 9780323189071
Senior undergraduates, medical students and other students in health-related fields, clinicians and researchers in the field of endocrinology, metabolism and biochemistry in general. Graduate students in medicine, pharmacy and biology+
