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Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine,

Edition 1

Editors: Edited by J. Miguel Oliveira, BSc, PhD, Rui L. Reis, PhD, DSc, Hon. Causa MD, Hon Causa PhD, FBSE, FTERM and Sandra Pina, BSc, MsC, PhD

Publication Date: 01 Dec 2023

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Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined.

Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health.

Key Features

Presents the fundamentals of the complex interplay of cells with biomaterials in musculoskeletal tissue engineering
Includes coverage of stem cells and cell-based therapies, in vitro and in vivo models, nanotechnology, bioprinting, computational modeling, regulatory and clinical translation, and much more
Written by global leaders in the field

About the author

Edited by J. Miguel Oliveira, BSc, PhD, Principal Investigator with Habilitation and Vice President of Institute 3B's, 3B’s Research Group, Institute 3B’s, University of Minho, Braga, Portugal; Rui L. Reis, PhD, DSc, Hon. Causa MD, Hon Causa PhD, FBSE, FTERM, President of Institute 3B’s, University of Minho; Director of the Associated Laboratory ICVS/3B’s and of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine (EXPERTISSUES); Full Professor of Tissue Engineering, Regenerative Medicine and Stem Cells, University of Minho, Barco, Portugal and Sandra Pina, BSc, MsC, PhD, Assistant Researcher, 3B’s Research Group, Institute 3B’s, University of Minho, Barco, Portugal

Section 1: Fundamentals of cell-biomaterials interactions
1. Introduction
2. Fundamentals and mechanisms
3. Cellular signaling processes
4. Cell-protein interactions
5. The microenvironment: Recreate the ECM
6. Surface modifications – topography, porosity
7. Chemotaxis: Soluble morphogens and Growth factors
8. Cell-biomaterials: Vascularization
9. Cell-biomaterials in Immunomodulation
10. Mechanobiology regulation
11. Electrical/Magnetic stimulation

Section 2: Multiscale design, structure/function and processing technologies
12. Introduction
13. Design of polymeric biomaterials at multiscale
14. Design of Calcium phosphates cements: Structure/function
15. Biomimetic micro-/nano- scales design
16. Cells-biomaterials structure-function at different length scales
17. Computational modelling involved in multiscale design
18. Hydrogel systems design: Structure/function
19. Scaffolding design and structure/function: Electrospinning
20. Scaffolding design and structure/function: Advanced manufacturing
21. Scaffolding design and structure/function: Bioprinting
22. Dynamic models for investigating structure/function of biomaterials: Bioreactors
23. Dynamic models for investigating cell-biomaterials interactions: Microfluidics
24. Complex in vitro models for studying cell-biomaterials interactions
25. In vivo animal models 26. Regulatory and clinical translation

ISBN: 9780323918213

Page Count: 554

Retail Price :

9781441980823; 9780387981604; 9781482256123

Students, Scientists, Professionals, Undergraduate and Graduate Students in Tissue Engineering, Regenerative Medicine, Biology, Bioengineering, Materials Science, and Nanotechnology