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Firestein & Kelley’s Textbook of Rheumatology, 2-Volume Set,

Edition 12

Editors: Edited by Gary S. Firestein, MD, Iain B. McInnes, PhD, FRCP, FRSE, FMedSci, Gary Koretzky, MD, Ted Mikuls, MD, Tuhina Neogi, MD, PhD and James R. O'Dell, MD

Publication Date: 09 Oct 2024

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**Selected for 2025 Doody’s Core Titles® with "Essential Purchase" designation in Rheumatology**

With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley’s Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field.

Key Features

Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment¿including key data on outcomes to better inform clinical decision making
Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more
Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients
Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi
Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints
An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date

About the author

Edited by Gary S. Firestein, MD, Distinguished Professor of Medicine, Senior Associate Vice Chancellor for Health Sciences, Director, Altman Clinical and Translational Research Institute, USA; Iain B. McInnes, PhD, FRCP, FRSE, FMedSci, Muirhead Professor of Medicine, Arthritis Research UK Professor of Rheumatology, Director of Institute of Infection,Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom; Gary Koretzky, MD, Vice Dean at Weill Cornell Medical College, Frank H.T. Rhodes Distinguished Professor of Cardiovascular Biology and Genetics, USA; Ted Mikuls, MD, Stokes Shackleford Professor and Vice-Chair for Research, Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, USA; Tuhina Neogi, MD, PhD, Section Chief of Rheumatology, Rheumatology, Professor, Rheumatology, Boston University School of Medicine, USA and James R. O'Dell, MD, Bruce Professor and Vice Chairman of Internal Medicine, University of Nebraska Medical Center, Chief of Rheumatology, Department of Medicine, Omaha Veterans Affairs, Omaha, Nebraska, USA

PART 1 Structure and Function of Bone, Joints, and Connective Tissue
1 Developmental Biology, Organization, and Function of the Synovial Joints
2 Synovium
3 Cartilage and Chondrocytes
4 Development and Biology of Bone
5 Muscle Anatomy, Physiology, and Biochemistry
6 Biomechanics
7 Regenerative Medicine and Tissue Engineering
8 Proteinases and Matrix Degradation

PART 2 Cells Involved in Autoimmune Diseases and Inflammation
9 Dendritic Cells
10 Mononuclear Phagocytes
11 Neutrophils
12 T Lymphocytes
13 B Cells
14 Fibroblasts andFibroblast-like Synoviocytes
15 Mast Cells and Basophils
16 Innate Lymphoid Cells and Natural Killer Cells
17 Platelets and Megakaryocytes

PART 3 Effector Mechanisms in Autoimmunity and Inflammation
18 Principles of Signaling
19 Innate Immunity
20 Adaptive Immunity
21 Immune Tolerance and Autoimmunity
22 Pre-clinical Autoimmunity
23 The Microbiome in Rheumatic Diseases
24 Genetics of Rheumatic Diseases
25 Epigenetics of Rheumatic Diseases
26 Complement System
27 Prostaglandins, Leukotrienes, and Related Compounds
28 Angiogenesis
29 Cytokines and Chemokines
30 Neuronal Mechanisms of Pain and Inflammation

PART 4 Broad Issues in the Approach to Rheumatic Disease
31 Clinical Research Methods in the Rheumatic Diseases
32 Epidemiology and Impact of Rheumatic Diseases
33 Assessment of Health Outcomes
34 Biomarkers in Rheumatology
35 Occupational, Environmental, and Recreational Musculoskeletal Disorders
36 Cardiovascular Risk in Inflammatory Rheumatic Disease
37 Cancer Risk in Rheumatic Diseases
38 Occupational Therapy, Physical Therapy, and Rehabilitation
39 General Principles of Pregnancy and Rheumatic Disease: Pre-pregnancy Assessment

PART 5 Evaluation of Generalized and Localized Symptoms
40 History and Physical Examination of the Musculoskeletal System
41 Ultrasound in Rheumatology
42 Evaluation of Monoarticular and Polyarticular Arthritis
43 Skin and Rheumatic Diseases
44 The Eye and Rheumatic Diseases

PART 6 Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain
45 Neck Pain
46 Shoulder Pain
47 Low Back Pain
48 Hip and Knee Pain
49 Foot and Ankle Pain
50 Hand and Wrist Pain
51 Temporomandibular Joint Disorders
52 Fibromyalgia

PART 7 Diagnostic Tests and Procedures in Rheumatic Diseases
53 Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology
54 Arthrocentesis and Injection of Joints and Soft Tissues
55 Anti-nuclear Antibodies
56 Autoantibodies in Rheumatoid Arthritis
57 Acute Phase Reactants
58 Imaging in Rheumatic Diseases

PART 8 Pharmacology of Anti-rheumatic Drugs
59 Therapeutic Targeting of Prostanoids
60 Glucocorticoid Therapy
61 Traditional DMARDs: Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies
62 Immunosuppressive Drugs
63 Anti-cytokine Biologics
64 Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics
65 Janus Kinase and Other Intra-cellular Targets
66 Urate-Lowering Therapy
67 Bisphosphonates
68 Analgesic Agents in Rheumatic Disease
69 Nutrition and Rheumatic Diseases

PART 9 Rheumatoid Arthritis and Sjögren’s Syndrome
70 Etiology of Rheumatoid Arthritis
71 Pathogenesis of Rheumatoid Arthritis
72 Clinical Features of Rheumatoid Arthritis
73 Treatment of Rheumatoid Arthritis
74 Sjögren’s Syndrome

PART 10 Spondyloarthritis
75 Classification and Epidemiology of Spondyloarthritis
76 Axial Spondyloarthritis
77 Reactive Arthritis
78 Psoriatic Arthritis
79 Inflammatory Bowel Disease–Associated Arthritis and Other Enteropathic Arthropathies

PART 11 Systemic Lupus Erythematosus and Related Syndromes
80 Etiology and Pathogenesis of Systemic Lupus Erythematosus
81 Clinical Features of Systemic Lupus Erythematosus
82 Treatment of Systemic Lupus Erythematosus
83 Antiphospholipid Syndrome

PART 12 Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes
84 Etiology and Pathogenesis of Systemic Sclerosis
85 Clinical Features and Treatment of Scleroderma
86 Inflammatory Diseases of Muscle and Other Myopathies
87 Overlap Syndromes

PART 13 Vasculitis
88 Classification and Epidemiology of Systemic Vasculitis
89 Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis
90 Anti-neutrophil Cytoplasmic Antibody–Associated Vasculitis
91 Polyarteritis Nodosa
92 Immune Complex–Mediated Small Vessel Vasculitis
93 Primary Central Nervous System Vasculitis
94 Behçet’s Disease

PART 14 Crystal-Induced and Inflammasome-Mediated Inflammation
95 Pathogenesis of Inflammasome-Mediated Diseases
96 Etiology and Pathogenesis of Hyperuricemia and Gout
97 Clinical Features and Treatment of Gout
98 Calcium Crystal Disease: Calcium Pyrophosphate Deposition Disease and Basic Calcium Phosphate-Associated Syndromes
99 Familial and Nonfamilial Autoinflammatory Syndromes

PART 15 Cartilage, Bone, and Heritable Connective Tissue Disorders
100 Etiology and Pathogenesis of Osteoarthritis
101 Clinical Features of Osteoarthritis
102 Treatment of Osteoarthritis
103 Metabolic Bone Disease
104 Proliferative Bone Diseases
105 Osteonecrosis
106 Relapsing Polychondritis
107 Heritable Diseases of Connective Tissues

PART 16 Rheumatic Diseases of Childhood
108 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis
109 Clinical Features and Treatment of Juvenile Idiopathic Arthritis
110 Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus
111 Juvenile Dermatomyositis, Scleroderma, and Vasculitis

PART 17 Infections and Rheumatic Disease
112 Bacterial Arthritis
113 Lyme Disease
114 Mycobacterial Infections of Bones and Joints
115 Fungal Infections of Bones and Joints
116 Rheumatic Manifestations of Human Immunodeficiency Virus Infection
117 Viral Arthritis
118 Rheumatic Fever and Post-streptococcal Arthritis
119 COVID-19 and Rheumatic Disease
120 Vaccination in Rheumatic Disease

PART 18 Arthritis Accompanying Systemic Disease
121 Amyloidosis
122 Sarcoidosis
123 Hemochromatosis
124 Hemophilic Arthropathy
125 Rheumatic Manifestations of Hemoglobinopathies
126 IgG4-Related Disease
127 Arthritis Accompanying Endocrine and Metabolic Disorders
128 Rheumatic Paraneoplastic Syndromes and Malignancies With Rheumatic Manifestations
129 Tumors and Tumor-like Lesions of Joints and Related Structures
130 Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer

Book Reviews

5 Stars! "...encompasses everything needed for professionals in rheumatology, providing an easy overview where topics can be readily found. The illustrations are helpful, and the videos included with the book enhance the learning experience. [It] is exceptionally comprehensive, allowing for thorough review of any topic necessary to fully grasp the latest updates in diagnoses and treatments, as well as the fundamental principles of rheumatology. The preface is particularly noteworthy, as it provides a clear overview of the book’s organization and offers a glimpse into the meticulous effort put into each chapter. The overall tone is informative and highly appreciated, ensuring that the audience is well-prepared to delve into the content. It covers a complete list of topics essential for understanding and treating rheumatology conditions, including pathophysiology, clinical manifestations, and treatment options. The book's comprehensive structure offers in-depth coverage across multiple dimensions, with detailed illustrations, high-quality artwork, and informative photographs supporting visual clarity." Review by Joseph Yusin, MD (VA Greater Los Angeles Healthcare System), ©Doody's Review Service 2025. Doody's Score: 100, 5 Stars!

ISBN: 9780323935401

Page Count: 2496

Illustrations : 1200

Retail Price :

Firestein & Kelley’s Textbook of Rheumatology, 2-Volume Set,

Editors: Edited by Gary S. Firestein, MD, Iain B. McInnes, PhD, FRCP, FRSE, FMedSci, Gary Koretzky, MD, Ted Mikuls, MD, Tuhina Neogi, MD, PhD and James R. O'Dell, MD

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About the author

Book Reviews