Diseases of the Nervous System,
Edition 1
By Harald Sontheimer

Publication Date: 12 Mar 2015
Description

The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles.

Diseases of the Nervous System summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine.

This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system.

Key Features

  • 2016 PROSE Award winner of the Best Textbook Award in Biological & Life Sciences
  • Provides a focused tutorial introduction to the core diseases of the nervous system
  • Includes comprehensive introductions to Stroke, Epilepsy, Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, ALS, Head and Spinal Cord Trauma, Multiple Sclerosis, Brain Tumors, Depression, Schizophrenia and many other diseases of the nervous system
  • Covers more than 40 diseases from the foundational science to the best treatment protocols
  • Includes discussions of translational research, drug discovery, personalized medicine, ethics, and neuroscience
About the author
By Harald Sontheimer, Harrison Distinguished Professor and Chair, Department of Neuroscience, University of Virginia, School of Medicine, Charlottesville, Virginia, USA
Table of Contents
  • Dedication
  • Part I. Static Nervous System Diseases
    • Chapter 1. Cerebrovascular Infarct: Stroke
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation/Diagnosis/ Epidemiology
      • 4. Disease Mechanism/Cause/Basic Science
      • 5. Treatment/Standard of Care/Clinical Management
      • 6. Experimental Approaches/Clinical Trials
      • 7. Challenges and Opportunities
    • Chapter 2. Central Nervous System Trauma
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation/Diagnosis/ Epidemiology
      • 4. Disease Mechanism/Cause/ Basic Science
      • 5. Treatment/Standard of Care/Clinical Management
      • 6. Experimental Approaches/Clinical Trials
      • 7. Challenges and Opportunities
    • Chapter 3. Seizure Disorders and Epilepsy
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation/Diagnosis/ Epidemiology
      • 4. Disease Mechanism/Cause/Basic Science
      • 5. Treatment/Standard of Care/Clinical Management
      • 6. Experimental Approaches/Clinical Trials
      • 7. Challenges and Opportunities
  • Part II. Progressive Neurodegenerative Diseases
    • Chapter 4. Aging, Dementia, and Alzheimer Disease
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation/Diagnosis/ Epidemiology
      • 4. Disease Mechanism/Cause/Basic Science
      • 5. Treatment/Standard of Care/Clinical Management
      • 6. Experimental Approaches/Clinical Trials
      • 7. Challenges and Opportunities
    • Chapter 5. Parkinson Disease
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation, Diagnosis and Epidemiology
      • 4. Disease Mechanism/Cause/Basic Science
      • 5. Treatment/Standard of Care/Clinical Management
      • 6. Experimental Approaches/Clinical Trials
      • 7. Challenges and Opportunities
    • Chapter 6. Diseases of Motor Neurons and Neuromuscular Junctions
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation/Diagnosis/ Epidemiology
      • 4. Disease Mechanism/Cause/Basic Science
      • 5. Treatment/Standard of Care/Clinical Management
      • 6. Experimental Approaches/Clinical Trials
      • 7. Challenges and Opportunities
    • Chapter 7. Huntington Disease
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation/Diagnosis/ Epidemiology
      • 4. Disease Mechanism/Cause/Basic Science
      • 5. Treatment/Standard of Care/Clinical Management
      • 6. Experimental Approaches/Clinical Trials
      • 7. Challenges and Opportunities
  • Part III. Secondary Progressive Neurodegenerative Diseases
    • Chapter 8. Multiple Sclerosis
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation/Diagnosis/ Epidemiology
      • 4. Disease Mechanism/Cause/Basic Science
      • 5. Treatment/Standard of Care/Clinical Management
      • 6. Experimental Approaches/Clinical Trials
      • 7. Challenges and Opportunities
    • Chapter 9. Brain Tumors
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation/Diagnosis/ Epidemiology
      • 4. Disease Mechanism/Cause/Basic Science
      • 5. Treatment/Standard of Care/Clinical Management
      • 6. Experimental Approaches/Clinical Trials
      • 7. Challenges and Opportunities
    • Chapter 10. Infectious Diseases of the Nervous System
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation/Diagnosis/Epidemiology/Disease Mechanism
      • 4. Beyond the Infection: Bona Fide Brain Disorders Involving Pathogens
      • 5. Experimental Approaches/Clinical Trials
      • 6. Challenges and Opportunities
  • Part IV. Developmental Neurological Conditions
    • Chapter 11. Neurodevelopmental Disorders
      • 1. Case Study
      • 2. History
      • 3. Development of Synapses in the Human Cortex and Diseases Thereof
      • 4. Down Syndrome
      • 5. Fragile X Syndrome
      • 6. Rett Syndrome
      • 7. Autism Spectrum Disorder
      • 8. Common Disease Mechanism
      • 9. Challenges and Opportunities
  • Part V. Neuropsychiatric Illnesses
    • Chapter 12. Mood Disorders and Depression
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation/Diagnosis/Epidemiology
      • 4. Disease Mechanism/Cause/Basic Science
      • 5. Treatment/Standard of Care/Clinical Management
      • 6. Experimental Approaches/Clinical Trials
      • 7. Challenges and Opportunities
    • Chapter 13. Schizophrenia
      • 1. Case Story
      • 2. History
      • 3. Clinical Presentation/Diagnosis/ Epidemiology
      • 4. Disease Mechanism/Cause/Basic Science
      • 5. Treatment/Standard of Care/Clinical Management
      • 6. Experimental Approaches/Clinical Trials
      • 7. Challenges and Opportunities
  • Part VI. Common Concepts in Neurological and Neuropsychiatric Illnesses
    • Chapter 14. Shared Mechanisms of Disease
      • 1. Introduction
      • 2. Neuronal Death
      • 3. Glutamate Toxicity
      • 4. Protein Aggregates and Prion-Like Spread of Disease
      • 5. Mitochondrial Dysfunction
      • 6. In Spite of Obvious Disease Heritability, Genetic Causes Often Remain Elusive
      • 7. Epigenetics
      • 8. Non-Cell-Autonomous Mechanisms
      • 9. Inflammation
      • 10. Vascular Abnormalities
      • 11. Brain-Derived Neurotrophic Factor
      • 12. Challenges and Opportunities
  • Part VII. Bench-To-Bedside Translation
    • Chapter 15. Drug Discovery and Personalized Medicine
      • 1. Introduction
      • 2. How Did We Get to This Point? A Brief History
      • 3. Drug Discovery: How Are Candidate Drugs Identified?
      • 4. What Are Clinical Trials and Why Do Them?
      • 5. The Placebo Effect
      • 6. Why Do Clinical Trials Fail?
      • 7. Personalized Medicine
      • 8. Challenges and Opportunities
  • Part VIII. Neuroscience Jargon
    • Chapter 16. “Neuro¿-dictionary

Book details
ISBN: 9780128002445
Page Count: 520
Retail Price : £125.00
  • Aminoff, Aminoff’s Neurology and General Medicine, 5th Edition, 9780124077102, 2014, $250.00
  • Zigmond, Neurobiology of Brain Disorders, 2014, 9780123982704, $99.95
  • Squire, Fundamental Neuroscience, 4E, 2012, 9780123858702, $109.95
  • Watson, The Brain: An Introduction to Functional Neuroanatomy, 9780123738899, 2010, $59.95
Instructor Resources
Audience

Students, researchers, practitioners and medical professionals in neuroscience and neurology