Drugs, Addiction, and the Brain - Edition 1 - By George F. Koob, Michael A. Arends, BS and Michel Le Moal Elsevier Health Inspection Copies

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Drugs, Addiction, and the Brain,

Edition 1

By George F. Koob, Michael A. Arends, BS and Michel Le Moal

Publication Date: 15 Jul 2014

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Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain.

Key Features

Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle
Actual data figures from original sources illustrating key concepts and findings
Introduction to basic neuropharmacology terms and concepts
Introduction to numerous animal models used to study diverse aspects of drug use.
Thorough review of extant work on the neurobiology of addiction

About the author

By George F. Koob, The Scripps Research Institute, La Jolla, CA, USA; Michael A. Arends, BS, Senior Research Assistant, The Scripps Research Institute, La Jolla, CA, USA and Michel Le Moal, Professor Emeritus, University of Bordeaux and Neurocentre Magendie, Inserm, Bordeaux, France

Preface
Chapter 1. What is Addiction?
- Definitions of Addiction
- Neuroadaptational Views of Addiction
- Summary
Chapter 2. Introduction to the Neuropsychopharmacology of Drug Addiction
- The Central Nervous System
- Pharmacology for Addiction
- Pharmacokinetics
- Basic Neurobiology of Addiction
- Brain Structures and Functions Relevant to the Three Stages of the Addiction Cycle
- Neuroadaptational Summary
Chapter 3. Animal Models of Addiction
- Validation of Animal Models of Drug Addiction
- Animal Models of the Binge/Intoxication Stage of the Addiction Cycle
- Animal Models of the Withdrawal/Negative Affect Stage of the Addiction Cycle
- Animal Models of the Preoccupation/Anticipation Stage of the Addiction Cycle
- Animal Models of Vulnerability to Addiction
- Summary of Animal Models of Addiction
Chapter 4. Psychostimulants
- Definitions
- History of Psychostimulant Use
- Physiological Effects
- Behavioral Effects
- Medical Uses
- Pharmacokinetics
- Behavioral Mechanism of Action
- Use, Abuse, and Addiction
- Neurobiological Effects
- Summary
Chapter 5. Opioids
- Definitions
- History of Opioid Use
- Physiological Effects
- Behavioral Effects
- Medical Uses
- Pharmacokinetics
- Behavioral Mechanism of Action
- Use, Abuse, and Addiction
- Neurobiological Effects
- Summary
Chapter 6. Alcohol
- Definitions
- History of Alcohol Use
- Behavioral Effects
- Pharmacokinetics
- Use, Abuse, and Addiction
- Alcohol Toxicity
- Behavioral Mechanism of Action
- Neurobiological Effects
- Summary
Chapter 7. Nicotine
- Definitions
- History of Use
- Medical Use and Behavioral Effects
- Pharmacokinetics
- Use, Abuse, and Addiction
- Behavioral Mechanism of Action
- Neurobiological Effects
- Summary
Chapter 8. Cannabinoids
- Definitions
- History of Cannabinoid Use
- Medical Uses
- Behavioral Effects
- Pharmacokinetics
- Use, Abuse, and Addiction
- Behavioral Mechanism of Action
- Neurobiological Effects
- Summary
Chapter 9. Medications for the Treatment of Addiction – A Neurobiological Perspective
- Conceptual Approach for Understanding Current and Future Medications Development
- Effects of Known Medications on Animal Models of Addiction – Reverse Validity (Rosetta Stone Approach)
- Novel Targets for Medication Development
- Human Laboratory Studies
- Individual Differences and Medication Development
- Clinical Trials – Unique Challenges and Opportunities
- Summary
Index

ISBN: 9780123869371

Page Count: 350

Retail Price : £78.99

Sanes, Development of the Nervous System 3^rd Edition, Academic Press, $89.95, 360pp, 2011, 9780123745392Siegel, Basic Neurochemistry 8^th Edition, Academic Press, $125.00, 1120pp, 2011, 9780123749475Baars, Cognition, Brain and Consciousness 2^nd Edition, Academic Press, $89.95, 672pp, 9780123750709

Advanced undergraduate and beginning graduate students taking an addiction course as part of a neuroscience, neurology, psychiatry, biology or addiction medicine program

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